While investigating where to fix the file descriptor limit in MySQL I ran across quite a few useful tweaks. The end result, I was able to shave about 300ms off of our page load speed for our WordPress site so that if you aren’t logged in, it is now under 1/2 second which ain’t shabby for WordPress.
There is still something causing MySQL to lock up. I am able to reproduce what is causing it, just don’t know how to fix it yet. I am trying to find a solution.